Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2)

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Professor Roger Seheult, MD explains the important role Vitamin D may have in the prevention and treatment of COVID-19. Dr. Seheult illustrates how Vitamin D works, summarizes the best available data and clinical trials on vitamin D, and discusses vitamin D dosage recommendations.

Roger Seheult, MD is the co-founder and lead professor at https://www.medcram.com
He is an Associate Professor at the University of California, Riverside School of Medicine and Assistant Prof. at Loma Linda University School of Medicine. Dr. Seheult is Quadruple Board Certified: Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine

Interviewer: Kyle Allred, Producer and Co-Founder of MedCram.com

REFERENCES:

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• Aging decreases the capacity of human skin to produce vitamin D3 (The J. of Clinical Investigation) | https://pubmed.ncbi.nlm.nih.gov/2997282/
• Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey (Osteoporosis Int.) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093445/
• Decreased bioavailability of vitamin D in obesity (The American J of Clinical Nutrition) | https://academic.oup.com/ajcn/article/72/3/690/4729361
• Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic? (Nutrients) | https://www.mdpi.com/2072-6643/12/8/2488
• Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data (BMJ) | https://www.bmj.com/content/356/bmj.i6583
• Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren (The American J.of Clinical Nutrition) | https://pubmed.ncbi.nlm.nih.gov/20219962/
• Vitamin D and SARS-CoV-2 infection—evolution of evidence supporting clinical practice and policy development (Irish J. of Medical Science) | https://link.springer.com/article/10.1007/s11845-020-02427-9
• Factors associated with COVID-19-related death using OpenSAFELY (Nature) | https://www.nature.com/articles/s41586-020-2521-4
• Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity (Alimentary Pharm. & Therap.) | https://pubmed.ncbi.nlm.nih.gov/32311755/
• The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality (Aging Clinical & Experimental Research) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202265/
• 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2 (Nutrients) | https://www.mdpi.com/2072-6643/12/5/1359
• Vitamin D deficiency in COVID-19: Mixing up cause and consequence (Metabolism) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671645/
• Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study (The FEBS J.) | https://pubmed.ncbi.nlm.nih.gov/32700398/
• The link between vitamin D deficiency and Covid-19 in a large population | https://www.medrxiv.org/content/10.1101/2020.09.04.20188268v1
• SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels (PLOS One) | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239252
• Vitamin D status and outcomes for hospitalised older patients with COVID-19 (Postgrad Medical J.) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456620/
• Vitamin D Deficiency and Outcome of COVID-19 Patients (Nutrients) | https://www.mdpi.com/2072-6643/12/9/2757
• “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study” (The J. of Steroid Bio. and Molec. Bio.) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/
• Vitamin D and survival in COVID-19 patients: A quasi-experimental study (The J. of Steroid Bio. and Molec. Bio.) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553119/
• Effect of Vitamin D3 Supplementation vs Placebo on Hospital Length of Stay in Patients with Severe COVID-19: A Multicenter, Double-blind, Randomized Controlled Trial | https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v1
• Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study) (Postgraduate Medical Journal) | https://pmj.bmj.com/content/early/2020/11/12/postgradmedj-2020-139065
• Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results (JAMA Network Open) | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2770157
• Vitamin D Fortification of Fluid Milk Products and Their Contribution to Vitamin D Intake and Vitamin D Status in Observational Studies—A Review (Nutrients) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116165/
• Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers (Scientific Reports from the Journal Nature) | https://www.nature.com/articles/s41598-020-77093-z

Relacionados:

• Tratamiento con calcifediol en pacientes hospitalizados de Covid-19
• Vitamina D y COVID-19, el endotelio y deficiencias